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As of now, long-term safety data is not available

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Clinical Evidence on Semaglutide Combined with Mental Health Medications Published clinical trials have not identified major contraindications between semaglutide and common antidepressants like sertraline, fluoxetine, or venlafaxine

A search of the TGAs database of adverse event notifications for the GLP-1 RA class up to September found there were 72 reports for suicidal ideation, six reports for depressional suicide, four reports of suicide attempt, two reports of completed suicide and one report of self-injurious ideation